Tetrabenazine therapy of pediatric hyperkinetic movement disorders
Identifieur interne : 003152 ( Main/Exploration ); précédent : 003151; suivant : 003153Tetrabenazine therapy of pediatric hyperkinetic movement disorders
Auteurs : Samay Jain [États-Unis] ; Paul E. Greene [États-Unis] ; Steven J. Frucht [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Anti-Dyskinesia Agents (therapeutic use), Child, Child, Preschool, Dose-Response Relationship, Drug, Drug Tolerance, Female, Follow-Up Studies, Humans, Hyperkinesia, Hyperkinesis (drug therapy), Infant, Male, Nervous system diseases, Pediatrics, Retrospective Studies, Tetrabenazine, Tetrabenazine (therapeutic use), Treatment, hyperkinetic movement disorders, pediatric movement disorders, pharmacotherapy, tetrabenazine.
- MESH :
- chemical , therapeutic use : Anti-Dyskinesia Agents, Tetrabenazine.
- drug therapy : Hyperkinesis.
- Adolescent, Child, Child, Preschool, Dose-Response Relationship, Drug, Drug Tolerance, Female, Follow-Up Studies, Humans, Infant, Male, Pediatrics, Retrospective Studies.
Abstract
Tetrabenazine (TBZ), a presynaptic dopamine depletor and postsynaptic dopamine receptor blocker, is widely used for the treatment of hyperkinetic movement disorders in adults. However, reports of its use in children are limited. We review the efficacy and tolerability of TBZ therapy in 31 children with hyperkinetic movement disorders refractory to other medications. TBZ was effective in reducing the severity of movement disorders resistant to treatment with other medicines. When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug‐induced Parkinsonism. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21063
Affiliations:
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Le document en format XML
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However, reports of its use in children are limited. We review the efficacy and tolerability of TBZ therapy in 31 children with hyperkinetic movement disorders refractory to other medications. TBZ was effective in reducing the severity of movement disorders resistant to treatment with other medicines. When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug‐induced Parkinsonism. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name></region><name sortKey="Frucht, Steven J" sort="Frucht, Steven J" uniqKey="Frucht S" first="Steven J." last="Frucht">Steven J. 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